Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men
Table 5
Case-control genotype associations with prostate cancer by non-Black and Black men (adjusted for age).
Variables of interest
Non–Black (South African Mixed and White)
Black (South African Black and Senegalese)
Genotypes
OR (95% CI)
OR (95% CI)
CYP3A4 (rs2740574)
AA
1.00 (ref)
1.00 (ref)
AG
3.58 (2.44–5.24)**
0.80 (0.35–1.82)
GG
5.16 (1.85–14.39)
0.65 (0.41–1.02)
AG/GG
3.95 (2.72–5.75)**
0.59 (0.26–1.31)
CYP3A5 (rs776746)
GG
1.00 (ref)
1.00 (ref)
AG
1.78 (1.23–2.58)
1.06 (0.24–4.63)
AA
1.30 (1.00–1.69)
1.08 (0.57–2.02)
AG/AA
1.75 (1.25–2.45)
1.13 (0.32–3.98)
SRD5A2 V89L (rs523349)
GG
1.00 (ref)
1.00 (ref)
CG
0.68 (0.48–0.96)
0.26 (0.11–0.61)*
CC
0.79 (0.52–1.20)
0.67 (0.46–0.97)*
CG/CC
0.67 (0.48–0.94)
0.38 (0.19–0.77)*
SRD5A2 A49T (rs9282858)
GG
1.00 (ref)
1.00 (ref)
AG
1.88 (1.30–2.73)
1.40 (0.48–4.12)
AA
—
—
AG/AA
1.88 (1.30–2.73)
1.40 (0.48–4.12)
—: too few/no genotypes to estimate ORs.
*
.
**
.
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