Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice

<table>Tumor imaging with YC-27 800CW. SCID Hairless mice implanted with 22Rv1 (right flank) and PC3 M-LN4 (left flank) cells received (a) 1X PBS, 100 <i>μ</i>L; (b) 800CW carboxylate, 1 nmol; (c) IgG 800CW, 75 <i>μ</i>g; (d) YC-27 800CW, 1 nmol (D/P = 1; SNR = 11.8); or (e) PSMA 800CW, 75 <i>μ</i>g (D/P = 1; SNR = 8.9), which was allowed to clear for 24 h prior to imaging on Pearl Impulse Imaging System. Signal is presented in pseudocolor. All images were normalized to the same LUT. White arrows indicate the location of the 22Rv1 tumor. Inset panels show the white light image of the mouse.</table>

Prostate Cancer

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Figure 3

Figure 3: Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice 