Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice

Figure 5

Fluorescence signal retention in specific clearance organs. (a) Tissue sections from mice receiving 1X PBS, carboxylate 800CW, IgG 800CW, PSMA 800CW, and YC-27 800CW were scanned on Odyssey CLx (21 micron). In all images, green indicates signals captured at 800 nm and red represents autofluorescence at 700 nm. Colocalization of the signals is yellow. (b) Higher magnification image (40x) of kidney renal cortex from YC-27 800CW treated mouse.