TY - JOUR A2 - Magi-Galluzzi, Cristina AU - Tanguturi, Shyam K. AU - Chen, Ming-Hui AU - Loffredo, Marian AU - Richie, Jerome P. AU - D’Amico, Anthony V. PY - 2014 DA - 2014/04/16 TI - Evaluating the Impact of PSA as a Selection Criteria for Nerve Sparing Radical Prostatectomy in a Screened Cohort SP - 395078 VL - 2014 AB - Purpose. We investigated whether NS-RP increased risk of PSA failure and whether PSA should be included as a selection criterion for NS. Methods. We evaluated 357 consecutive men with screen-detected PC who underwent open RP without adjuvant radiotherapy between 9/11/2001 and 12/30/2008. Criteria for NS included Gleason score ≤3 + 4, percentage of positive biopsies (PPB) ≤50%, percentage of core involvement ≤50%, nonapical location, no perineural invasion, and no palpable disease on pre- or intraoperative exam but did not include a PSA threshold. Cox multivariable regression assessed whether increasing PSA or unilateral- or bilateral-NS versus non-NS-RP was associated with PSA failure adjusting for prognostic factors. Results. After a median follow-up of 3.96 years, 34 men sustained PSA failure (9.5%). Increasing PSA was significantly associated with increased risk of PSA failure in the interaction model (adjusted hazard ratio (AHR): 1.09 [95% CI: 1.03–1.16]; P=0.005), whereas unilateral (AHR: 1.24 [95% CI: 0.36–4.34]; P=0.73) or bilateral NS (AHR: 0.41 [95% CI: 0.06–2.59]; P=0.34) versus non-NS RP was not. Conclusion. NS-RP in a screened cohort did not increase risk of PSA failure using NS criteria not including PSA. SN - 2090-3111 UR - https://doi.org/10.1155/2014/395078 DO - 10.1155/2014/395078 JF - Prostate Cancer PB - Hindawi Publishing Corporation KW - ER -