Clinical Study

Comparison of Transperineal Mapping Biopsy Results with Whole-Mount Radical Prostatectomy Pathology in Patients with Localized Prostate Cancer

Table 4

Sensitivity and specificity of TMB for detection of prostate cancer, overall and separately by quadrant, using RP specimen pathology as gold standard.

Cancer in specimenSensitivity %
(95% CI)
Specificity %
(95% CI)
Positive predictive value
(95% CI)
Negative predictive value
(95% CI)
YesNo

Overall
Cancer in biopsyYes38486 (72–94)83 (62–95)90 (77–97)77 (56–91)
No620

By Quadrant
Left anteriorCancer in biopsyYes10191 (58–99)83 (35–99)91 (58–99)83 (35–99)
No15
Right anteriorCancer in biopsyYes9275 (42–94)60 (14–94)81 (48–97)50 (11–88)
No33
Left posteriorCancer in biopsyYes91100 (66–100)88 (47–99)90 (55–99) 100 (59–100)
No07
Right posteriorCancer in biopsyYes10083 (51–97) 100 (47–100)100 (69–100)71 (29–96)
No25

By Anterior/posterior
Left Anterior + Right AnteriorCancer in biopsyYes19383 (61–95)73 (39–93)86 (65–97)67 (34–90)
No48
Left Posterior + Right PosteriorCancer in biopsyYes19190 (69–98)92 (63–99)95 (75–99)85 (57–98)
No212

By Right/left
Right Anterior +
Right Posterior
Cancer in biopsyYes19279 (57–92)80 (44–97)90 (69–98)62 (31–86)
No58
Left Anterior +
Left Posterior
Cancer in biopsyYes19295 (75–99)86 (57–98)90 (69–98)92 (63–99)
No112