Clinical Study
Comparison of Transperineal Mapping Biopsy Results with Whole-Mount Radical Prostatectomy Pathology in Patients with Localized Prostate Cancer
Table 4
Sensitivity and specificity of TMB for detection of prostate cancer, overall and separately by quadrant, using RP specimen pathology as gold standard.
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Cancer in specimen | Sensitivity % (95% CI) | Specificity % (95% CI) | Positive predictive value (95% CI) | Negative predictive value (95% CI) | | | | Yes | No |
| Overall | | | | | | | | | | Cancer in biopsy | Yes | 38 | 4 | 86 (72–94) | 83 (62–95) | 90 (77–97) | 77 (56–91) | | No | 6 | 20 |
| By Quadrant | | | | | | | | Left anterior | Cancer in biopsy | Yes | 10 | 1 | 91 (58–99) | 83 (35–99) | 91 (58–99) | 83 (35–99) | No | 1 | 5 | Right anterior | Cancer in biopsy | Yes | 9 | 2 | 75 (42–94) | 60 (14–94) | 81 (48–97) | 50 (11–88) | No | 3 | 3 | Left posterior | Cancer in biopsy | Yes | 9 | 1 | 100 (66–100) | 88 (47–99) | 90 (55–99) | 100 (59–100) | No | 0 | 7 | Right posterior | Cancer in biopsy | Yes | 10 | 0 | 83 (51–97) | 100 (47–100) | 100 (69–100) | 71 (29–96) | No | 2 | 5 |
| By Anterior/posterior | | | | | | | | Left Anterior + Right Anterior | Cancer in biopsy | Yes | 19 | 3 | 83 (61–95) | 73 (39–93) | 86 (65–97) | 67 (34–90) | No | 4 | 8 | Left Posterior + Right Posterior | Cancer in biopsy | Yes | 19 | 1 | 90 (69–98) | 92 (63–99) | 95 (75–99) | 85 (57–98) | No | 2 | 12 |
| By Right/left | | | | | | | | Right Anterior + Right Posterior | Cancer in biopsy | Yes | 19 | 2 | 79 (57–92) | 80 (44–97) | 90 (69–98) | 62 (31–86) | No | 5 | 8 | Left Anterior + Left Posterior | Cancer in biopsy | Yes | 19 | 2 | 95 (75–99) | 86 (57–98) | 90 (69–98) | 92 (63–99) | No | 1 | 12 |
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