Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants

Table 5

Association between prostate tissue Trx 1 and erythrocyte glutathione S-transferase activity.

	Erythrocyte glutathione S-transferase (GST)
	T1		T2		T3		Total
		%		%		%
Malignant Trx 1
0	2	(50)	1	(25)	1	(25)	4
1	4	(57)	0	(0)	3	(42)	7
2	4	(20)	10	(50)	6	(30)	20
3	6	(42)	5	(35)	3	(21)	14
Fisher’s exact test,
Benign Trx 1
0	0	(0)	1	(100)	0	(0)	1
1	8	(28)	11	(39)	9	(32)	28
2	7	(53)	3	(23)	3	(23)	13
3	1	(33)	1	(33)	1	(33)	3
Fisher’s exact test,
ΔTrx 1
−2	1	(50)	1	(50)	0	(0)	2
−1	2	(50)	1	(25)	1	(25)	4
0	6	(42)	2	(14)	6	(42)	14
1	5	(29)	7	(41)	5	(29)	17
2	2	(28)	4	(57)	1	(14)	7
3	0	(0)	1	(100)	0	(0)	1
Total	16		16		13		45
Fisher’s exact test,

ΔTrx 1: difference in Trx 1 level between malignant and benign prostate cells.
Median values of tertiles of GST activity are as follows: T1: 19.9 nmol/min/mL; T2: 49.7 nmol/min/mL; T3: 84.4 nmol/min/mL.