Review Article

The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?

Figure 1

EMT in cancer metastasis. (a) Schematic representation of the role of EMT in cancer metastasis. (b) A cascade of transcriptional regulation underlies the transition from an epithelial to a mesenchymal phenotype, and (c) during EMT, epithelial markers are downregulated while mesenchymal markers are upregulated.
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