Review Article

Management of Patients with Nonmetastatic Castration-Resistant Prostate Cancer: Recommendations of a Multidisciplinary Panel of Experts from South America

Box 3

Recommendations regarding adverse events in the treatment of patients with M0CRPC.
(i) Second-generation antiandrogens are considered overall safe, provided that treatment is prescribed according to current indications
(ii)Signs of cognitive decline should be proactively watched out for during treatment with second-generation antiandrogens
(iii)The inclusion of specific questionnaires for monitoring cognitive function in M0CRPC patients treated with second-generation antiandrogens may be useful to enhance the safety of these therapies