Research Article

Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study

Table 3

Comparison of genotype ratios of IL-6 rs1800795 and IL-8 rs2227306 SNPs in the affected and the control groups.

Frequencies of genotypesCancer versus control®BPH versus control®
Cancer (n = 40)BPH (n = 40)Control (n = 40)1OR1 (95%CI) (LL–UL)2OR2 (95%CI) (LL–UL)

IL-6 rs1800795
 CC versus (CG + GG)8 (20%)9 (22.5%)25 (62.5%)<0.0010.1500 (0.055–0.410)<0.0010.174 (0.065–0.464)
 CG versus (CC + GG)14 (35%)25 (62.5%)12 (30%)0.6331.256 (0.492–3.209)0.0043.889 (1.533–9.868)
 GG versus (CC + CG)18 (45%)6 (15%)3 (7.5%)0.00110.091 (2.665–38.204)0.2972.177 (0.504–9.391)

IL-8 rs2227306
 CC versus (CT + TT)12 (30%)3 (7.5%)2 (5%)0.0098.143 (1.686–39.319)0.6461.541 (0.243–9.755)
 CT versus (CC + TT)17 (42.5%)24 (60%)16 (40%)0.8201.109 (0.455–2.701)0.0762.250 (0.920–5.504)
 TT versus (CC + CT)11 (27.5%)13 (32.5%)22 (55%)0.0140.310 (0.122–0.789)0.0450.394 (0.159–0.978)

®: reference group, OR: odds ratio, CI: confidence interval, UL: upper limit, LL: lower limit. OR1, 1: odds ratio and value for comparing between cancer and control. OR2, 2: odds ratio and p value for comparing between BPH and control. Statistically significant at  ≤ 0.05.