Optimal PSA Threshold for Obtaining MRI-Fusion Biopsy in Biopsy-Naïve Patients

Table 2

PSA thresholds when targeted biopsy plus standard biopsy detected more clinically significant prostate cancer than standard biopsy alone.

PSA threshold (greater than X)	Targeted + standard	Standard	Difference	P value	Sensitivity (%)	Specificity (%)
3.5	6	5	1	1.000	95.9	7.7
4.0	11	9	2	0.500	93.5	11.0
4.1	13	10	3	0.250	92.3	13.2
4.2	16	11	5	0.063	90.5	15.4
4.3	20	14	6	0.031	88.2	19.8
4.4	24	18	6	0.031	85.8	22.0
4.5	27	21	6	0.031	84.0	25.3
4.8	36	27	9	0.004	78.7	31.9
5.0	47	33	14	<0.001	72.2	34.1
5.2	51	36	15	<0.001	69.8	40.7
5.5	57	40	17	<0.001	66.3	44.0
6	72	50	22	<0.001	57.4	51.6
7	83	59	24	<0.001	50.9	64.8
10	134	96	38	<0.001	20.7	90.1

PSA = prostate-specific antigen.