Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease
Figure 2
Neuroprotection against 6-OHDA toxicity following delayed subchronic intranigral administration of 2R,4R-APDC (10 nmol in 4 L) translates into functional recovery of motor deficits. (a) Bar graph of mean percentage forelimb use asymmetry s.e.m in vehicle and 2R,4R-APDC (10 nmol)-treated animals, , vehicle versus 2R,4R-APDC. (b) Bar graph of amphetamine-induced rotational behavior, expressed as net ipsilateral turns over 60 minutes s.e.m in vehicle and 2R,4R-APDC-treated animals, , vehicle versus 2R,4R-APDC.