Parkin Exon Rearrangements and Sequence Variants in LRRK2 Mutations Carriers: Analysis on a Possible Modifier Effect on LRRK2 Penetrance

Table 2

Study of families with LRRK2 mutations.

Subjects with	PD Patients with LRRK2 mutations	Not affected relatives with LRRK2 mutations	Not affected relatives without LRRK2 mutations
G2019S	7	10	3
Mutation	(5 M/2 F)	(4 M/6 F)	(1 M/2 F)
R1441C	2	0	3
Mutation	(2 F)		(2 M/1 F)
Total	9	10	6
(25)	(5 M/4 F)	(4 M/6 F)	(3 M/3 F)

M: Male; F: Female.