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Parkinson’s Disease
Volume 2010, Article ID 650794, 16 pages
Research Article

Effects of Various Flavonoids on the -Synuclein Fibrillation Process

1Department of Chemistry, University of California, Santa Cruz, CA 95064, USA
2Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Institute for Intrinsically Disordered Protein Research, Indiana University School of Medicine, 410 W. 10th Street, HS 5009, Indianapolis, IN 46202, USA
3Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow 142290, Russia

Received 26 May 2009; Revised 8 September 2009; Accepted 23 October 2009

Academic Editor: Mark Robert Cookson

Copyright © 2010 Xiaoyun Meng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary materials represent experimental details of the inhibitory activities of each flavonoid analyzed in this study (Table S1). Data presented in Figure S1 illustrate instant changes in the intensity of ThT fluorescence upon adding 50 μM flavonoids directly to the solution of existing α‐synuclein fibrils.

  1. Supplementary Materials