Review Article

Total Cholesterol and the Risk of Parkinson's Disease: A Review for Some New Findings

Table 1

Prospective studies of total cholesterol and the risk of Parkinson’s disease.

Lead author, year [ref.]Samples or controls/casesAge (years)SexMean values of cholesterol (case : control) (mmol/L) -value for differenceRelative risk (95% CI)Adjusted for confounding factors

Case-control studies

Teunisse et al., 2003 [8]61/4668/706.41 : 5.59n.s.
Sohmiya et al., 2004 [9]29/3659/634.65 : 4.20n.s.
Sciglian et al., 2006 [10]533/17860/58Both0.89 (0.68–1.15)Age and sex
Huang et al., 2007 [11]112/12466/68Both5.19 : 4.96n.s.

Cohort studies

Grandinetti et al., 1994 [12]8006/5853MaleHigh cholesterol (yes/no): 0.73 (0.43–1.24)Age
Huang et al., 2008 [13]3222/4177Male
De Lau et al., 2006 [14]3811/4169FemalePer 1.0 mmol/L increase:Age and sex
2654/4668Male0.77 (0.64–0.94)
Simon et al., 2007 [15]121 046/26442FemaleHigh cholesterol (yes/no):Age, smoking, hypertension, diabetes
50 833/26654Male0.98 (0.82–1.19)
Per 1.0 mmol/L increase:Age, sex, body mass index, systolic blood pressure, education, leisure time physical activity, smoking, coffee, tea, and alcohol consumption, cholesterol-lowering agent use, and history of diabetes
Hu et al., 2008 [16]26 153/30444Female1.09 (1.02–1.16) for both
24 773/321 44Male1.10 (1.01–1.21) for men
1.07 (0.98–1.17) for women

n.s.: not significant.