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Parkinson’s Disease
Volume 2011, Article ID 125271, 7 pages
Clinical Study

The Possible Clinical Predictors of Fatigue in Parkinson’s Disease: A Study of 135 Patients as Part of International Nonmotor Scale Validation Project

1National Parkinson Foundation Centre of Excellence, King’s College Hospital, King’s College London, Denmark Hill Campus, 9th Floor, Ruskin Wing, London SE5 9RS, UK
2University Hospital Lewisham, London SE13 6LH, UK
3University of Surrey, Surrey GU2 7XH, UK
4Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain
5Department of Neurology, University Hospital, Lund University, Lund, Sweden
6Department of Neurology, Central Hospital, Reinkenheide, Bremerhaven, Germany
7Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
8Department of Neurology, IRCCS San Raffaele, 00163 Rome, Italy
9Department of Neurology, IRCCS San Camillo Venice and University of Padua, 35122 Padua, Italy

Received 23 December 2010; Revised 14 September 2011; Accepted 14 September 2011

Academic Editor: Antonio Strafella

Copyright © 2011 Vinod Metta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Fatigue is a common yet poorly understood and underresearched nonmotor symptom in Parkinson’s disease. Although fatigue is recognized to significantly affect health-related quality of life, it remains underrecognised and empirically treated. In this paper, the prevalence of fatigue as measured by a validated visual analogue scale and the Parkinson’s disease nonmotor symptoms scale (PDNMSS) was correlated with other motor and nonmotor comorbidities. In a cohort of patients from a range of disease stages, occurrence of fatigue correlated closely with more advanced Parkinson’s disease, as well as with depression, anxiety, and sleep disorders, hinting at a common underlying basis.