MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse

<table>Neuronal morphology totals.  Total spine density (a), average highest branch order (b), and total dendrite length (c) in saline-injected (unshaded panel) and MPTP-treated (shaded panel) gonad-intact (black bars) and orchidectomized (white bars) male mice (<svg height="10.925" id="M34" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> mice/group).  Bars represent an effect of MPTP (<svg height="11.375" id="M35" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 50.549999 11.375" width="50.549999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>). OrchX: orchidectomized; Sham: sham-orchidectomized.</table>

Parkinson’s Disease

fig3

Figure 3

Figure 3: MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse 