Differential Effects of Dopaminergic Therapies on Dorsal and Ventral Striatum in Parkinson's Disease: Implications for Cognitive Function

Table 1

Cognitive functions that are enhanced, unchanged, or impaired by dopaminergic therapy, grouped according to their association with dorsal striatum, ventral striatum, or other brain regions.

	Enhanced by dopaminergic therapy	Unchanged by dopaminergic therapy	Impaired by dopaminergic therapy
Ventral striatum	*Motivation		Implicit and explicit learning
	*Impulsivity		Reversal learning
			Orienting to stimuli
Dorsal striatum	Selective attention	Complex planning	Time estimation
	Selective responding	Set shifting
	Complex planning	Task switching
	Category judgements
	Time estimation
	Visuospatial processing
	Explicit and implicit retrieval
	Set shifting
	Task switching
Other brain regions	Spatial working memory	Nonspatial working memory	Simple reaction time
	Manipulating contents of working memory	Set shifting	Production of self-generated sequences
		Task switching	Generation of alternate uses of common objects

*Are enhanced to a pathological degree.