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Parkinson’s Disease
Volume 2011, Article ID 737523, 8 pages
Review Article

The Role of Cognitive-Behavioural Therapy for Patients with Depression in Parkinson's Disease

1Institute of Neurology, The National Hospital for Neurology and Neurosurgery, University College London (UCL), Queen Square, London WC1N 3BG, UK
2Department of Clinical Neurosciences, Institute of Neurology, University College London, Royal Free Campus, London NW3 2PF, UK

Received 7 December 2010; Accepted 25 February 2011

Academic Editor: Dag Aarsland

Copyright © 2011 Andreas Charidimou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Depression is a common complication of Parkinson's disease (PD) with considerable impact on patients' quality of life. However, at present the most appropriate treatment approach is unclear. There are limited data on antidepressant medications in PD-associated depression (dPD) and those available suggest limited efficacy and tolerability of these drugs. Cognitive behavioural therapy (CBT) has been shown to be an effective treatment of depressive disorders. Treatment of dPD with CBT may pose particular challenges, including possible different pathophysiology, physical and mental comorbidities, and barriers to treatment through disability, which do not allow simple transfer of these results to patients with dPD. However, a number of case reports, case series, and small pilot studies suggest that this is a promising treatment for patients with PD. We here summarise the published evidence on this treatment in dPD.