An NR2B-Dependent Decrease in the Expression of trkB Receptors Precedes the Disappearance of Dopaminergic Cells in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Disease
Photomicrographs showing a decrease in the number of trkB-IR cells in ipsilateral SNc at 7 and 14 days, but not at 4 days, after unilateral 6-OHDA intrastriatal injections. Photomicrographs show trkB-immunoreactive (IR) cells in the contralateral (a), (c), and (e) and ipsilateral (b), (d), and (f) sides of rat SN at 4, 7, and 14 days after unilateral intrastriatal injection of 6-OHDA. (a)–(f) scale bar = 100 mm. SNc: substantia nigra pars compacta; SNR: substantia nigra pars reticulata.