The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5^′Untranslated-Region-Directed Translation Blockers of the Parkinson’s Alpha Synuclein Expression

Figure 7

A model for translation repression of alpha-synuclein in which its transcript interacts with an RNA repressor protein. In the classical translation repression model, Iron-regulatory protein-1 (IRP1) controls iron dependent expression of the ferritin L- and H-chains. By analogy, phenserine, posiphen and its metabolic analogs would be predicted to increase the repressor as an RNA binding protein to interact with the SNCA 5′UTR after drug treatment. This should prohibit 40S ribosome access to the 5′UTR of SNCA mRNA to lower translation.