Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies

Figure 2

Schematic Illustration on 3D of the autophagy flux. The first step consists of the formation of isolation membranes (phagophore) and elongation of this membrane for sequester the material to degraded (autophagosome). Finally a lysosome is fused with the autophagosome (autophagolysosome) and the cargo is degraded.