Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies

Table 1

Genes associated with Parkinson’s disease linkage.

Gene	Locus	Protein name	Inheritance pattern	Description
PARK 1/4	4q21.3-q22	𝛼-synuclein (SNCA)	AD	Lewy’s body component
PARK 2	6q25.2-27	Parkin	AR	E3 ubiquitin-protein ligase
PARK 3	2p13	¿?	AD	¿?
PARK 5	4p14	UCH-L1	AD	Ubiquitin C-terminal hydrolase
PARK 6	1p35-36	PINK1	AR	Mitochondrial kinase
PARK 7	1p36	DJ-1	AR	Chaperone mitochondrial kinase
PARK 8	12q12	LRRK2	AD	Kinase/GTPase
PARK 9	1p36	ATP13A2	AR	Cationic transport
PARK 10	1p32	¿?	AD	¿?
PARK 11	2q36-q37	GIGYF2	AD	Receptor tyrosine phosphorylation regulation
PARK 12	Xq21-q25	¿?	X-linked	¿?
PARK 13	2p13	HTRA2/OMI	AD	Serine protease
PARK 14	22q13.1	PLA2G6	AR	Phospholipase A2
PARK 15	22q11.2	FBXO7	AR	E3 ubiquitin-protein
PARK 16	1q32	¿?	¿?	ligase¿?

AD: autosomal dominant; AR: autosomal recessive.