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Parkinson’s Disease
Volume 2012, Article ID 198316, 15 pages
Review Article

Nonmotor Symptoms in Parkinson’s Disease in 2012: Relevant Clinical Aspects

1APHP, Department of Neurology, Hospital Pitié-Salpêtrière, Paris, France
2INSERM, APHP, ICM, Centre d’Investigation Clinique, CIC-9503, Hospital Pitié-Salpêtrière, Paris, France
3INSERM, CR-ICM, UMRS 975, Hospital Pitié-Salpêtrière, Paris, France

Received 3 February 2012; Accepted 18 April 2012

Academic Editor: Marjan Jahanshahi

Copyright © 2012 Anne Marie Bonnet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nonmotor symptoms (NMSs) of Parkinson’s disease (PD) are common, but they are often underrecognized in clinical practice, because of the lack of spontaneous complaints by the patients, and partly because of the absence of systematic questioning by the consulting physician. However, valid specific instruments for identification and assessment of these symptoms are available in 2012. The administration of the self-completed screening tool, NMSQuest, associated with questioning during the consultation, improves the diagnosis of NMSs. NMSs play a large role in degradation of quality of life. More relevant NMSs are described in this review, mood disorders, impulse control disorders, cognitive deficits, hallucinations, pain, sleep disorders, and dysautonomia.