| Musculoskeletal: aching, cramping, arthralgic, myalgic sensations in joints, and muscles; may exacerbated by parkinsonian rigidity, stiffness, and immobility, postural abnormalities, and relieved by mobility; may be associated rheumatologic and orthopaedic disease. May fluctuate with medication dosing, and improve with levodopa. | | Dystonic: associated with sustained twisting movements and postures; muscular contractions often very forceful and painful; may fluctuate closely with medication dosing: wearing off dystonia, early morning dystonia, peak-dose dystonia, diphasic dystonia. | | Radicular/Neuropathic: pain in a root or nerve territory, associated with motor or sensory signs of nerve or root entrapment. | | Central or primary pain: burning, tingling, formication, “neuropathic” sensations, often relentless and bizarre in quality, not confined to root or nerve territory; pain may have an autonomic character, with visceral sensations or dyspnea, and vary in parallel with the medication cycle as a non-motor fluctuation; not explained by rigidity, dystonia, musculoskeletal or internal lesion. | | Akathisia: subjective sense of restlessness, often accompanied by urge to move; may fluctuate with medication effect, and improve with levodopa. | | Others types of pain: oral and genital pain; burning mouth or vagina syndrome; may represent a sensory wearing off and may improve with L-dopa. | |
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