Parkinson’s Disease / 2012 / Article / Tab 1

Research Article

Adenosine A 𝟐 A Receptor Antagonists Do Not Disrupt Rodent Prepulse Inhibition: An Improved Side Effect Profile in the Treatment of Parkinson's Disease

Table 1

Mean startle magnitude ± SEM in rat prepulse inhibition (* versus vehicle).

DrugDose (mg/kg)Startle

SCH 412348Veh.193.3 ± 46.6
0.3223.4 ± 59.5
1.0166.0 ± 20.2
3.0213.0 ± 46.3

IstradefyllineVeh.196.5 ± 50.8
0.1163.7 ± 26.7
0.3161.5 ± 23.3
1.0175.0 ± 36.9

PramipexoleVeh.229.5 ± 32.1
0.3121.4 ± 14.4*
1.0134.7 ± 32.0*
3.0101.6 ± 14.2*

PergolideVeh.139.9 ± 20.7
0.3104.9 ± 27.1
1.0111.0 ± 19.1
3.084.0 ± 11.1

RopiniroleVeh.250.2 ± 49.7
1.0218.8 ± 33.7
3.073.0 ± 17.6*
10.0166.6 ± 26.7
30.0111.4 ± 22.1*

L-dopaVeh.228.7 ± 124.7
10183.5 ± 31.0
30269.8 ± 63.7
100239.0 ± 45.1
300197.2 ± 49.8

ApomorphineVeh.303.2 ± 46.3
0.3323.5 ± 44.3
0.5456.3 ± 140.0
0.65468.1 ± 76.2
0.8355.2 ± 79.6

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