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Parkinson’s Disease
Volume 2012, Article ID 614212, 8 pages
Research Article

Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain

1Department of Neurology, Boston University School of Medicine, Boston, MA 02119, USA
2The Graduate Program in Bioinformatics, Boston University, Boston, MA 02215, USA
3Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
4Whitehead Institute for Biomedical Research, Cambridge, MA, USA

Received 4 November 2011; Accepted 19 December 2011

Academic Editor: Kathleen A. Maguire-Zeiss

Copyright © 2012 Alexandra Dumitriu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The Supplementary Materials contain the following information: 1) a description of the neuropathological criteria used to define the Alzheimer disease variable discussed in Section 2.3 of Materials and Methods (Table 1), 2) a scatter plot of age at death and SNCA-FL expression values (after adjustment for pH, PMI, and sex) in controls, which shows a significant association (Figure 1), and 3) the scatter plots and predicted regression lines for SNCA-FL expression (after adjustment for age at death, pH, PMI, sex and disease status-PMI interaction) in PD cases and controls for the whole range of available postmortem intervals and for postmortem intervals up to 5.5 hours (Figure 2).

  1. Supplementary Material