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Parkinson’s Disease
Volume 2012 (2012), Article ID 793076, 9 pages
Research Article

Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease

1Department of Psychology, Boston University, Boston, MA 02215, USA
2Psychology Research (151-A), VA Boston Healthcare System, 150 South Huntington Street, Boston, MA 02130, USA
3Department of Psychiatry, Boston University School of Medicine, Boston, MA 02118, USA
4Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA

Received 31 July 2011; Accepted 25 October 2011

Academic Editor: Antonio Lucio Teixeira

Copyright © 2012 Yelena Bogdanova and Alice Cronin-Golomb. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Parkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesized that PD patients would show different neuropsychiatric and neurocognitive profiles depending on the side of onset. 22 nondemented PD patients (11 right-side onset (RPD) with predominant left-hemisphere pathology, and 11 LPD) and 22 matched healthy controls (NC) were administered rating scales assessing apathy and anxiety, and a series of neuropsychological tests. PD patients showed a higher anxiety level than NC. There was a significant association between apathy, anxiety, and disease duration. In LPD, apathy but not anxiety was associated with performance on nonverbally mediated executive function and visuospatial measures, whereas, in RPD, anxiety but not apathy correlated with performance on verbally mediated tasks. Our findings demonstrated a differential association of apathy and anxiety to cognition in PD.