17𝜶-Ethynyl-androst-5-ene-3𝜷,7𝜷,17𝜷-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease

Figure 1

HE3286 readily penetrates the BBB. CD-1 mice (males, n = 3 per group) were treated (gavage) with HE3286 (80 mg/kg HE3286) and sacrificed at 0.5, 1, 2, 3, 4, 8, and 24 h. Serum and brain samples were analyzed for HE3286 by LC-MS/MS. Each point represents the mean value derived from three animals.