| | | Parkinson’s disease with GERD (n = 27) | Parkinson’s disease without GERD (n = 75) | P value |
| | Gender, n (%) | | | | | Female | 16 (59.3) | 42 (56.0) | NS | | Male | 11 (40.7) | 33 (44.0) | NS | | Age, y, mean ± SD (range) | 69.8 ± 9.5 (56–91) | 70.4 ± 7.9 (48–88) | NS | | Onset age, y, mean ± SD (range) | 62.6 ± 9.8 (38–78) | 64.5 ± 9.2 (40–83) | NS | | LEDD, mg, mean ± SD | 766.3 ± 449.9 | 653.7 ± 334.0 | NS | | MMSE, mean ± SD | 26.9 ± 2.8 | 26.4 ± 2.4 | NS | | Heartburn, n (%) | 12 (44.4) | 10 (13.3) | <0.001 | | Bent forward flexion, n (%) | 10 (37.0) | 13 (17.3) | 0.04 | | Disease duration, m, (range) | 91.6 ± 50.5 (12–241) | 76.2 ± 49.5 (6–218) | NS | | H&Y stage, mean ± SD | 2.2 ± 0.8 | 2.2 ± 0.9 | NS | | Stage 0, n (%) | 0 (0) | 2 (2.7) | | Stage 1, n (%) | 5 (18.5) | 10 (13.3) | | Stage 2, n (%) | 13 (48.1) | 40 (53.3) | | Stage 3, n (%) | 8 (29.6) | 17 (22.7) | | Stage 4, n (%) | 1 (3.7) | 6 (8.0) | | UPDRS | | | | | Total, mean ± SD (range) | 35.3 ± 13.9 (1–56) | 28.4 ± 14.3 (3–73) | 0.02 | | Part II, mean ± SD (range) | 14.6 ± 7.0 (5–29) | 8.8 ± 6.2 (0–25) | <0.001 | | Part III, mean ± SD (range) | 17.0 ± 8.7 (4–36) | 17.6 ± 10.1 (0–46) | NS | | Wearing-off phenomenon, n (%) | 13 (48.1) | 16 (21.3) | <0.01 | | PDQ-39, mean ± SD (range) | 56.3 ± 31.7 (3–134) | 29.8 ± 24.7 (0–108) | <0.001 | | NMSS, mean ± SD (range) | 50.9 ± 34.0 (9–135) | 22.9 ± 22.4 (0–117) | <0.0001 |
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