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Parkinson’s Disease
Volume 2014 (2014), Article ID 819260, 7 pages
Research Article

Comparison of the Psychological Symptoms and Disease-Specific Quality of Life between Early- and Typical-Onset Parkinson’s Disease Patients

1Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Novum 5th Floor, 14186 Stockholm, Sweden
2Firoozgar Clinical Research Development Center (FCRDC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran 15937-48711, Iran
3Medical Student Research Committee (MSRC), Faculty of Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran
4Movement Disorders Clinic, Department of Neurology, Faculty of Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran
5Iranian Research Center on Aging, University of Social Welfare and Rehabilitation, Tehran 19857-13834, Iran
6Department of Geriatric Medicine, Karolinska University Hospital, 14186 Stockholm, Sweden

Received 27 July 2014; Revised 13 December 2014; Accepted 14 December 2014; Published 29 December 2014

Academic Editor: Hélio Teive

Copyright © 2014 Seyed-Mohammad Fereshtehnejad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The impact of Parkinson’s disease (PD) on psychological status and quality of life (QoL) may vary depending on age of disease onset. The aim of this study was to compare psychological symptoms and disease-specific QoL between early onset versus the rest of the PD patients. A total number of 140 PD patients with the mean current age of 61.3  yr were recruited in this study. PD patients with the onset age of ≤50 yr were defined as “early-onset” (EOPD) group , while the ones with >50 yr at the time of diagnosis were categorized as the “typical-onset” (TOPD) patients . Different questionnaires and scales were used for between-group comparisons including PDQ39, HADS (hospital anxiety and depression scale), FSS (fatigue severity scale), MNA (mininutritional assessment), and the UPDRS. Depression score was significantly higher in EOPD group (6.3 versus 4.5 , ). Among different domains of QoL, emotion score was also significantly higher in the EOPD group (32.3 versus 24.4 , ). Our findings showed more severe depression and more impaired emotional domain of QoL in early-onset PD patients. Depression and anxiety play an important role to worsen QoL among both EOPD and TOPD patients, while no interaction was observed in the efficacy of these two psychiatric symptoms and the onset age of PD patients.