Research Article

Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease

Figure 4

Pentoxifylline treatments (PTX: 10, 25, and 50 mg/kg, 15 days) reverse in part striatal dopamine (DA) and DOPAC depletions in the 6-OHDA group, relatively to the untreated 6-OHDA group. The values are means ± SEM from 6 to 10 animals per group. L and R correspond to the left (unlesioned) and right (lesioned) sides of the rat striata. (a) DA: A versus 6-OHDA L, ; B versus 6-OHDA + PTX10 L, ; C versus 6-OHDA + PTX25 L, ; D versus 6-OHDA + PTX50 L, ; F versus 6-OHDA R, . (b) DOPAC: A versus 6-OHDA L, ; B versus 6-OHDA + PTX10 L, ; C versus 6-OHDA R, ; D versus 6-OHDA + PTX25 L, ; E versus 6-OHDA + PTX50, (two-tailed Student’s t-test).
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