Levetiracetam Ameliorates L-DOPA-Induced Dyskinesia in Hemiparkinsonian Rats Inducing Critical Molecular Changes in the Striatum

Figure 3

Levetiracetam-induced expression changes of the ΔFosB and phosphorylation of ERK1/2 in the dorsolateral portion of the striatum. Images display immunoblots from striatal tissue (IL: ipsilateral side; CL: contralateral side) from one animal in each levetiracetam treatment group, and immunoblots correspond to FosB, ΔFosB, and β-actin as internal control. Levetiracetam 60 mg/kg significantly reduced the striatal ΔFosB expression (a). versus same side of control group ( per group; LEV: levetiracetam). Images display immunoblots from striatal tissue (IL: ipsilateral side; CL: contralateral side) from one animal in each levetiracetam treatment group, and immunoblots correspond to p-ERK1/2 and β-actin as internal control. Levetiracetam 30 and 60 mg/kg significantly reduced the striatal p-ERK1/2 expression (b). and versus same side of the control group ( per group; LEV: levetiracetam).

(a)

(b)