Changes to Intermediary Metabolites in Sporadic and LRRK2 Parkinson’s Disease Demonstrated by Proton Magnetic Resonance Spectroscopy

Figure 3

PLS-DA scores and loadings of LV1 separating Parkinson’s disease patients with LRRK2 mutations from patients with sporadic disease. Metabolite numbers: (1) -D-glucose, (2) ascorbate, (3) myo-inositol, (4) dimethyl sulphone, (5) creatinine, (6) creatine, (7) citrate, (8) pyruvate, (9) glutamine, (10) alanine, (11) lactate, (12) 3-hydroxybutyrate, (13) 3-hydroxyisobutyrate, (14) valine, (15) leucine, and (16) 2-hydroxybutyrate.