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Parkinson’s Disease
Volume 2015, Article ID 490507, 7 pages
Clinical Study

Personality Changes after Deep Brain Stimulation in Parkinson’s Disease

1Department of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital-Rikshospitalet, 0027 Oslo, Norway
2Department of Gerontopsychiatry, Akershus University Hospital, 1478 Lørenskog, Norway
3Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway
4Department of Neurosurgery, Oslo University Hospital-Rikshospitalet, 0027 Oslo, Norway
5Department of Neurology, Oslo University Hospital-Rikshospitalet, 0027 Oslo, Norway
6Department of Biostatistics and Epidemiology, Oslo University Hospital-Rikshospitalet, 0450 Oslo, Norway
7Department of Psychology, University of Oslo, 0316 Oslo, Norway
8Centre for Age-Related Medicine, Stavanger University Hospital, 4068 Stavanger, Norway
9Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 17176 Stockholm, Sweden

Received 27 November 2014; Accepted 4 January 2015

Academic Editor: Elan D. Louis

Copyright © 2015 Uyen Pham et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a recognized therapy that improves motor symptoms in advanced Parkinson’s disease (PD). However, little is known about its impact on personality. To address this topic, we have assessed personality traits before and after STN-DBS in PD patients. Methods. Forty patients with advanced PD were assessed with the Temperament and Character Inventory (TCI): the Urgency, Premeditation, Perseverance, Sensation Seeking impulsive behaviour scale (UPPS), and the Neuroticism and Lie subscales of the Eysenck Personality Questionnaire (EPQ-N, EPQ-L) before surgery and after three months of STN-DBS. Collateral information obtained from the UPPS was also reported. Results. Despite improvement in motor function and reduction in dopaminergic dosage patients reported lower score on the TCI Persistence and Self-Transcendence scales, after three months of STN-DBS, compared to baseline (; ). Relatives reported significantly increased scores on the UPPS Lack of Premeditation scale at follow-up (). Conclusion. STN-DBS in PD patients is associated with personality changes in the direction of increased impulsivity.