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Parkinson’s Disease
Volume 2015 (2015), Article ID 547065, 11 pages
http://dx.doi.org/10.1155/2015/547065
Research Article

Association between Community Ambulation Walking Patterns and Cognitive Function in Patients with Parkinson’s Disease: Further Insights into Motor-Cognitive Links

1Center for the Study of Movement, Cognition, and Mobility, Department of Neurology, Tel Aviv Sourasky Medical Center, 64239 Tel Aviv, Israel
2Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, 6997801 Tel Aviv, Israel
3Sagol School of Neuroscience, Tel Aviv University, 6997801 Tel Aviv, Israel
4Sieratzki Chair of Neurology, Tel Aviv University, 6997801 Tel Aviv, Israel
5Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, 6997801 Tel Aviv, Israel

Received 27 April 2015; Revised 10 September 2015; Accepted 4 October 2015

Academic Editor: Jan O. Aasly

Copyright © 2015 Aner Weiss et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Cognitive function is generally evaluated based on testing in the clinic, but this may not always reflect real-life function. We tested whether parameters derived from long-term, continuous monitoring of gait are associated with cognitive function in patients with Parkinson’s disease (PD). Methods. 107 patients with PD (age: 64.9 ± 9.3 yrs; UPDRS motor sum “off”: 40.4 ± 13.2; 25.23% women) wore a 3D accelerometer on their lower back for 3 days. Computerized measures of global cognitive function, executive function, attention, and nonverbal memory were assessed. Three-day acceleration derived measures included cadence, variability, bilateral coordination, and dynamic postural control. Associations between the acceleration derived measures and cognitive function were determined. Results. Linear regression showed associations between vertical gait variability and cadence and between global cognitive score, attention, and executive function (). Dynamic postural control was associated with global cognitive score and attention (). Nonverbal memory was not associated with the acceleration-derived measures. Conclusions. These findings suggest that metrics derived from a 3-day worn body-fixed sensor reflect cognitive function, further supporting the idea that the gait pattern may be altered as cognition declines and that gait provides a window into cognitive function in patients with PD.