Modulation of stem cells or dopaminergic (DA) cells with combined cellular transplantation in PD.
|Type of transplanted cells||Animal model||Significance||Reference|
|Mouse fetal DA neurons||Mouse mesencephalic NSCs overexpressing human glial-derived neurotrophic factor (GDNF-mNSCs)||6-OHDA rat ||Apomorphine-induced rotation was reduced by cotransplantation of fetal DA neurons with mNSCs genetically modified to overexpress GDNF, which supports differentiation into DA cells and their survival|||
|Human embryonic NSC||Macaque autologous Schwann cells (SCs)||6-OHDA macaque ||Gomez-Mancilla dyskinesia score in the group of cotransplantation with SCs and NSCs was significantly lower than the control group. SCs harvested from the autologous peripheral nerves can avoid rejection|||
|Human umbilical cord-derived MSCs||Human dermal fibroblasts||MPTP rat ||Fibroblasts may be common cell contaminants affecting purity of MSC preparations and clinical outcome in stem cell therapy protocols|||
|Rat embryonic DA neurons||Rat Schwann cells (SCs) overexpressing basic fibroblast growth factor (FGF-2)||6-OHDA rat ||Cotransplantation of DA neurons and FGF-2 overexpressing SCs differentially affects survival and reinnervation. Behavioral recovery underlines the necessity of direct contact between FGF-2 and DA neurons|||