Medical Record Review to Differentiate between Idiopathic Parkinson’s Disease and Parkinsonism: A Danish Record Linkage Study with 10 Years of Follow-Up
Table 3
Comorbidities reported in the National Hospital Register by type of Parkinsonism prior to Parkinsonism diagnosis or interview.
Group
Diagnosis
Total
Linked to National
Heart disease
CVD
Peripheral vascular disease
Diabetes
Cancer
COPD
Dementia
Hospital Register
%
value
%
value
%
value
%
value
%
value
%
-value
%
-value
Cases
IPD
2068
2068
179
8.7
0.047
247
11.9
<0.0001
101
4.9
0.178
110
5.3
0.742
235
11.4
0.921
128
6.2
0.122
126
6.1
<0.0001
IPD interviewed
1813
1813
152
8.4
0.102
183
10.1
0.005
88
4.9
0.205
89
4.9
0.808
199
11.0
0.783
103
5.7
0.033
76
4.2
<0.0001
LBD
53
53
4
7.5
0.784
12
22.6
0.001
7
13.2
0.006
4
7.5
0.348
9
17.0
0.197
2
3.8
0.428
34
64.2
<0.0001
MSA
44
44
6
13.6
0.125
3
6.8
0.232
1
2.3
1.000
1
2.3
0.723
5
11.4
1.000
4
9.1
0.566
2
4.5
0.0215
PSP + CBD
21
21
1
4.8
1.000
5
23.8
0.018
1
4.8
0.578
3
14.3
0.092
2
9.5
1.000
2
9.5
0.667
3
14.3
0.0002
Sec. + other types of Parkinsonism
125
125
21
16.8
<0.0001
55
44.0
<0.0001
11
8.8
0.010
13
10.4
0.011
18
14.4
0.287
14
11.2
0.126
23
18.4
<0.0001
Essential tremor
35
35
8
22.9
0.003
10
28.6
0.0002
4
11.4
0.053
7
20.0
0.002
3
8.6
0.791
9
25.7
0.001
0
0.0
1.0000
Enrolled controls
NA
1887
1829
127
6.9
136
7.4
73
4.0
93
5.1
206
11.3
136
7.4
8
0.4
Comorbidities were defined as ever diagnosis of each type of disease in the National Hospital Register (HNR) from 1977 to 2009. Pearson’s chi-square test was performed to compare the proportions of each comorbidity between Parkinsonism cases and enrolled controls. For comparisons where 25% of the cells have expected counts less than 5, Fisher’s exact was performed instead.
