Research Article
Effect of GBA Mutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and a Meta-Analysis
Table 1
Results of our own data in Chinese and attributes of all included studies.
| First author | Country | Group | Number | Family history | AAO () | Tremor () | Bradykinesia () | H-Y () | UPDRS-III () | Dementia () | Dyskinesia () |
| Our own data | China | GBA + PD | 34 | 1 | 50.18 ± 9.44 | 21 | 23 | 2.82 ± 0.97 (14) | 33.43 ± 23.02 (14) | 5 (6) | 6 (14) | GBA − PD | 1113 | 37 | 54.75 ± 11.52 | 694 | 768 | 2.41 ± 0.95 (410) | 21.55 ± 3.84 (410) | 171 (262) | 99 (410) |
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Wang 2014 [6] | China | GBA + PD | 49 | — | 51.45 ± 9.14 | 26 (49) | 18 (45) | 2.02 ± 0.68 | 25.80 ± 13.49 | — | 5 (37) | GBA − PD | 1366 | — | 58.41 ± 11.03 | 723 (1362) | 475 (1362) | 1.94 ± 0.78 | 23.35 ± 13.95 | — | 76 (922) |
| Pulkes 2014 [7] | China | GBA + PD | 17 | 4 | 43.1 ± 10.2 | — | — | — | — | — | 7 | GBA − PD | 191 | 18 | 54.4 ± 13.9 | — | — | — | — | — | 24 |
| Malec-Litwinowicz 2014 [8] | Poland | GBA + PD | 5 | — | 57.2 ± 2.8 | — | — | 2.9 ± 1.0 | 36.4 ± 18.5 | 3 | — | GBA − PD | 171 | — | 57.6 ± 10.9 | — | — | 2.2 ± 0.8 | 23.9 ± 12.3 | 23 | — |
| Li 2014 [9] | Japan | GBA + PD | 34 | 34 | 49.1 ± 11.7 | — | — | — | — | 12 | 10 | GBA − PD | 113 | 113 | 51.3 ± 14.5 | — | — | — | — | 18 | 37 |
| Asselta 2014 [10] | Italy | GBA + PD | 102 | 21 | 51.54 ± 10.63 | — | — | — | — | — | — | GBA − PD | 2182 | 250 (2153) | 56.69 ± 10.51 | — | — | — | — | — | — |
| Kumar 2013 [11] | Serbia | GBA + PD | 21 | 2 (18) | 49.68 ± 9.68 (19) | 6 (15) | 4 (14) | 2.74 ± 0.77 (19) | — | — | 0 (19) | GBA − PD | 339 | 54 (297) | 52.40 ± 11.1 (302) | 151 (280) | 78 (280) | 2.40 ± 0.79 (303) | — | — | 2 (287) |
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Kresojević 2013 [12] | Serbia | GBA + PD | 18 | — | 53.0 ± 8.2 | — | — | 2.7 ± 1.1 | 38.6 ± 21.4 | — | — | GBA − PD | 32 | — | 53.3 ± 10.0 | — | — | 2.4 ± 0.8 | 35.9 ± 15.5 | — | — |
| Wang 2012 [13] | China | GBA + PD | 7 | | 56.14 ± 8.34 | — | — | — | — | — | — | GBA − PD | 208 | | 56.78 ± 13.08 | — | — | — | — | — | — |
| Setó-Salvia 2012 [14] | Europe | GBA + PD | 22 | 11 | 54.2 ± 6.6 | — | — | 2.5 ± 0.82 | — | 11 | — | GBA − PD | 203 | 79 | 56.5 ± 12.7 | — | — | 2.67 ± 0.98 | — | 48 | — |
| Emelyanov 2012 [15] | Russia | GBA + PD | 9 | 3 | — | — | — | — | — | — | — | GBA − PD | 321 | 97 | — | — | — | — | — | — | — |
| de Carvalho Guimarães 2012 [16] | Brazil | GBA + PD | 13 | 2 | — | — | — | — | — | — | — | GBA − PD | 334 | 79 | — | — | — | — | — | — | — |
| Alcalay 2012 [17] | Multisites | GBA + PD | 33 | — | — | — | — | — | — | 11 (26) | — | GBA − PD | 114 | — | — | — | — | — | — | 6 (39) | — |
| Lesage 2011 [18] | Europe | GBA + PD | 100 | 69 | 51.0 ± 12.7 (96) | 45 (88) | 64 (88) | 1.9 ± 0.8 (52) | 19 ± 11 (56) | — | 21 (75) | GBA − PD | 1291 | 717 | 50.0 ± 13.7 (1220) | 635 (1076) | 641 (1069) | 2.1 ± 0.9 (743) | 19 ± 13 (792) | — | 263 (894) |
| Huang 2011 [19] | China | GBA + PD | 36 | — | — | — | — | — | — | — | — | GBA − PD | 931 | — | — | — | — | — | — | — | — |
| Mao 2010 [20] | China | GBA + PD | 20 | — | 54.90 ± 11.97 | 6 (20) | 12 (20) | 2.55 ± 1.04 | — | — | — | GBA − PD | 596 | — | 54.63 ± 12.21 | 181 (596) | 293 (596) | 2.29 ± 0.98 | — | — | — |
| Gan-Or 2010 [21] | Israel | GBA + PD | 109 | 27 | — | 57 | 27 | — | — | — | — | GBA − PD | 402 | 85 | — | 236 | 61 | — | — | — | — |
| Socal 2009 [22] | Brazil | GBA + PD | 6 | — | 37.5 ± 2.7 | — | — | — | — | — | — | GBA − PD | 53 | — | 41.4 ± 10 | — | — | — | — | — | — |
| De Marco 2008 [23] | Italy | GBA + PD | 11 | — | — | — | — | — | — | 3 | — | GBA − PD | 384 | — | — | — | — | — | — | 5 | — |
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(): number of patients whose clinical information was available.
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