Research Article

Effect of GBA Mutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and a Meta-Analysis

Table 1

Results of our own data in Chinese and attributes of all included studies.

First authorCountryGroupNumberFamily historyAAO ()Tremor ()Bradykinesia ()H-Y ()UPDRS-III ()Dementia
()
Dyskinesia
()

Our own dataChinaGBA + PD34150.18 ± 9.4421232.82 ± 0.97 (14)33.43 ± 23.02 (14)5 (6)6 (14)
GBA − PD11133754.75 ± 11.526947682.41 ± 0.95 (410)21.55 ± 3.84 (410)171 (262)99 (410)

Wang 2014 [6]ChinaGBA + PD4951.45 ± 9.1426 (49)18 (45)2.02 ± 0.6825.80 ± 13.495 (37)
GBA − PD136658.41 ± 11.03723 (1362)475 (1362)1.94 ± 0.7823.35 ± 13.9576 (922)

Pulkes 2014 [7] ChinaGBA + PD17443.1 ± 10.27
GBA − PD1911854.4 ± 13.924

Malec-Litwinowicz 2014 [8] PolandGBA + PD557.2 ± 2.82.9 ± 1.036.4 ± 18.53
GBA − PD17157.6 ± 10.92.2 ± 0.823.9 ± 12.323

Li 2014 [9] JapanGBA + PD343449.1 ± 11.71210
GBA − PD11311351.3 ± 14.51837

Asselta 2014 [10] ItalyGBA + PD1022151.54 ± 10.63
GBA − PD2182250 (2153)56.69 ± 10.51

Kumar 2013 [11] SerbiaGBA + PD212 (18)49.68 ± 9.68 (19)6 (15)4 (14)2.74 ± 0.77 (19)0 (19)
GBA − PD33954 (297)52.40 ± 11.1 (302)151 (280)78 (280)2.40 ± 0.79 (303)2 (287)

Kresojević 2013 [12] SerbiaGBA + PD1853.0 ± 8.22.7 ± 1.138.6 ± 21.4
GBA − PD3253.3 ± 10.02.4 ± 0.835.9 ± 15.5

Wang 2012 [13] ChinaGBA + PD756.14 ± 8.34
GBA − PD20856.78 ± 13.08

Setó-Salvia 2012 [14] EuropeGBA + PD221154.2 ± 6.62.5 ± 0.8211
GBA − PD2037956.5 ± 12.72.67 ± 0.9848

Emelyanov 2012 [15] RussiaGBA + PD93
GBA − PD32197

de Carvalho Guimarães 2012 [16] Brazil GBA + PD132
GBA − PD33479

Alcalay 2012 [17] Multisites GBA + PD3311 (26)
GBA − PD1146 (39)

Lesage 2011 [18] EuropeGBA + PD1006951.0 ± 12.7 (96)45 (88)64 (88)1.9 ± 0.8 (52)19 ± 11 (56)21 (75)
GBA − PD129171750.0 ± 13.7 (1220)635 (1076)641 (1069)2.1 ± 0.9 (743)19 ± 13 (792)263 (894)

Huang 2011 [19] ChinaGBA + PD36
GBA − PD931

Mao 2010 [20] ChinaGBA + PD2054.90 ± 11.976 (20)12 (20)2.55 ± 1.04
GBA − PD59654.63 ± 12.21181 (596)293 (596)2.29 ± 0.98

Gan-Or 2010 [21] IsraelGBA + PD109275727
GBA − PD4028523661

Socal 2009 [22] BrazilGBA + PD637.5 ± 2.7
GBA − PD5341.4 ± 10

De Marco 2008 [23] ItalyGBA + PD113
GBA − PD3845

(): number of patients whose clinical information was available.