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Parkinson’s Disease
Volume 2015, Article ID 926280, 4 pages
http://dx.doi.org/10.1155/2015/926280
Research Article

Association Analysis of COQ2 Variant in Dementia and Essential Tremor

1Department of Neurology, Singapore General Hospital, Singapore 169608
2National Neuroscience Institute, Singapore 308433
3Duke-NUS Graduate Medical School, Singapore 169857
4Health Assessment Centre, Singapore General Hospital, Singapore 169608
5Health Services Research, Singapore General Hospital, Singapore 169608
6Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore 308433
7Department of Clinical Research, Singapore General Hospital, Singapore 169608

Received 2 February 2015; Accepted 2 April 2015

Academic Editor: Hélio Teive

Copyright © 2015 Yin Xia Chao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. COQ2 mutations have been reported in Japanese multiple system atrophy (MSA) patients. We examined the role of COQ2 in patients with dementia and essential tremor (ET), two common neurodegenerative conditions. Materials & Methods. A total of 2064 subjects, including 560 patients with dementia, 466 patients with ET, and 1038 healthy controls, were included. Genotyping for the COQ2 V393A (T>C) was carried out. Odds ratio (OR) adjusted by age and gender, together with 95% confidence interval (CI), was reported by means of logistic regression. Results. The frequency of the polymorphic variant V393A heterozygous (T/C) was 2.7% in dementia, 1.1% in ET, and 2.5% in controls (OR = 0.70, 95% confidence interval is 0.29–1.72 for dementia, and OR = 0.47, 95% confidence interval is 0.17–1.31, for ET). There was no significant association between V393A variant with dementia and ET. Conclusion. There was no significant association between V393A variant with dementia and ET. COQ2 gene is unlikely to play a significant role in patients with dementia or ET in our population.