Table of Contents Author Guidelines Submit a Manuscript
Parkinson’s Disease
Volume 2015, Article ID 926280, 4 pages
http://dx.doi.org/10.1155/2015/926280
Research Article

Association Analysis of COQ2 Variant in Dementia and Essential Tremor

1Department of Neurology, Singapore General Hospital, Singapore 169608
2National Neuroscience Institute, Singapore 308433
3Duke-NUS Graduate Medical School, Singapore 169857
4Health Assessment Centre, Singapore General Hospital, Singapore 169608
5Health Services Research, Singapore General Hospital, Singapore 169608
6Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore 308433
7Department of Clinical Research, Singapore General Hospital, Singapore 169608

Received 2 February 2015; Accepted 2 April 2015

Academic Editor: Hélio Teive

Copyright © 2015 Yin Xia Chao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Bhalerao and T. R. Clandinin, “Cell biology. Vitamin K2 takes charge,” Science, vol. 336, no. 6086, pp. 1241–1242, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Salama, T. F. Yuan, S. Machado et al., “Co-Enzyme Q10 to treat neurological disorders: basic mechanisms, clinical outcomes, and future research direction,” CNS and Neurological Disorders—Drug Targets, vol. 12, no. 5, pp. 641–644, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Quinzii, A. Naini, L. Salviati et al., “A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency,” The American Journal of Human Genetics, vol. 78, no. 2, pp. 345–349, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Mitsui, T. Matsukawa, and H. Ishiura, “Mutations in COQ2 in familial and sporadic multiple-system atrophy,” The New England Journal of Medicine, vol. 369, no. 3, pp. 233–244, 2013, Erratum to The New England Journal of Medicine, vol. 371, no. 1, pp. 94, 2014. View at Publisher · View at Google Scholar
  5. C. H. Lin, E. K. Tan, C. C. Yang, Z. Yi, and R. M. Wu, “COQ2 gene variants associate with cerebellar subtype of multiple system atrophy in Chinese,” Movement Disorders, vol. 30, no. 3, pp. 436–437, 2015. View at Google Scholar
  6. C. H. Lin, H. I. Lin, M. L. Chen, and R. M. Wu, “COQ2 p.V393A variant, rs148156462, is not associated with Parkinson's disease in a Taiwanese population,” Neurobiology of Aging, vol. 36, no. 1, pp. 546.e17–546.e18, 2015. View at Publisher · View at Google Scholar
  7. YP. Chen, B. Zhao, B. Cao et al., “Mutation scanning of the COQ2 gene in ethnic Chinese patients with multiple-system atrophy,” Neurobiology of Aging, vol. 36, no. 2, pp. 1222.e7–1222.e11, 2015. View at Publisher · View at Google Scholar
  8. X. Yang, J. Xi, R. An et al., “Lack of evidence for an association between the V393A variant of COQ2 and amyotrophic lateral sclerosis in a Han Chinese population,” Neurological Sciences, 2015. View at Publisher · View at Google Scholar
  9. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders: DSM-IV, American Psychiatric Association, Washington, DC, USA, 4th edition, 1994.
  10. G. McKhann, D. Drachman, M. Folstein et al., “Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease,” Neurology, vol. 34, no. 7, pp. 939–944, 1984. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Deuschl, P. Bain, and M. Brin, “Consensus statement of the movement disorder society on tremor. Ad Hoc scientific committee,” Movement Disorders, vol. 13, supplement 3, pp. 2–23, 1998. View at Google Scholar
  12. M. Forsgren, A. Attersand, S. Lake et al., “Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ,” Biochemical Journal, vol. 382, no. 2, pp. 519–526, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. B. S. Jakobs, L. P. van den Heuvel, R. J. P. Smeets et al., “A novel mutation in COQ2 leading to fatal infantile multisystem disease,” Journal of the Neurological Sciences, vol. 326, no. 1-2, pp. 24–28, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Turunen, J. Olsson, and G. Dallner, “Metabolism and function of coenzyme Q,” Biochimica et Biophysica Acta—Biomembranes, vol. 1660, no. 1-2, pp. 171–199, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Dhanasekaran and J. Ren, “The emerging role of coenzyme Q-10 in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus,” Current Neurovascular Research, vol. 2, no. 5, pp. 447–459, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. M. A. Desbats, G. Lunardi, M. Doimo, E. Trevisson, and L. Salviati, “Genetic bases and clinical manifestations of coenzyme Q10 (CoQ10) deficiency,” Journal of Inherited Metabolic Disease, vol. 38, no. 1, pp. 145–156, 2015. View at Publisher · View at Google Scholar