5-HT2A Receptor Binding in the Frontal Cortex of Parkinson’s Disease Patients and Alpha-Synuclein Overexpressing Mice: A Postmortem Study
receptor mouse prefrontal cortex autoradiography binding analysis and gene expression levels. (a) Results from [3H] MDL 100.907 () binding. FrA [3H] MDL 100.907 binding is significantly lower in alpha-synuclein overexpressing (SNCA) mice compared to wt mice. Bars: grey: wild-type mice (); black: SNCA mice (). . Multiple -test. Data illustrated with mean ± SEM. (b) Results from RT-qPCR show CT ratios (calculated using CT-ratio (receptor/reference) = ) comparing alpha-synuclein overexpressing (SNCA) and wt mice. Reference genes are Rpl13a and GAPDH. No difference in receptor gene expression was found. Bars show mean ± SEM.
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