A Case-Control Association Study of RANTES (-28C>G) Polymorphism as a Risk Factor for Parkinson’s Disease in Isparta, Turkey

Table 2

Genotype and allele frequencies of IL-8 (-251A>T), MCP-1 (-2518A>G), RANTES (-28C>G), CCR-2 (V64I), and CCR-5 (-Δ32) polymorphisms. Statistically significant values are in bold (HWE: Hardy-Weinberg equilibrium, MAF: minor allele frequency, OR: odds ratio, and 95% CI: 95% confidence interval).

Polymorphism	Groups	Genotypes			HWE	MAF	Association; analyses	Genetic model (OR 95% CI/p value)				Armittage’s; trend test
								Allele	Homozygous	Dominant	Recessive
					(p value)
		AA	AT	TT				A versus T	AA versus TT	AA versus AT + TT	AA + AT versus TT	Common odds ratio and p value
IL-8; (-251A/T)	Case	11	9	10	0.032	0.483	Case versus control	0.582	0.331	0.266	1.158	0,605; p = 0.106
		(0,36)	(0,30)	(0,33)				[0.311–1.087]	C.I. = [0.102–1.074]	[0.093–0.760]	[0.460–2.914]
	Control	8	30	22	0.787	0.617		p = 0.088	p = 0.061	p = 0.011	p = 0.755
	()	(0,13)	(0,50)	(0,37)
		AA	AG	GG				A versus G	AA versus GG	AA versus AG + GG	AA + AG versus GG	Common odds ratio and p value
MCP-1 (-2518A/G)	Case	21	4	5	0.002	0.233	Case versus; control	0.837	1.571	0.524	0.455	1.032; p = 0.664
	()	(0,70)	(0,13)	(0,17)				[0.406–1.723]	[0.405–6.092]	[0.206–1.330]	[0.121–1.713]
	Control	33	22	5	0.740	0.267
	()	(0,55)	(0,37)	(0,08)				p = 0.629	p = 0.511	p = 0.171	p = 0.236
		CC	CG	GG				C versus G	CC versus GG	CC versus CG + GG	CC + CG versus GG	Common odds ratio and p value
RANTES (-28C/G)	Case	24	3	3	0.007	0.150	Case versus; control	44.456	17.286	32.102	0.065	4.580; p = 0.0007
	()	(0,80)	(0,10)	(0,10)				[2.540–778.197]	[0.860–347.237]	[1.741–591.937]	[0.003–1.301]
	Control	60	0	0	0.001	0.000		p = 0.001	p = 0.009	p = 0.001	p = 0.013
	)	(1,00)	(0,00)	(0,00)
		GG	GA	AA				G versus A	GG versus AA	GG versus GA + AA	GG + GA versus AA	Common odds ratio and p value
CCR2; (V64I); (+190G/A)	Case	23	7	0	1.000	0.117	Case versus control	0.588	1.638	0.526	0.504	0.526; p = 0.202
	()	(0,77)	(0,23)	(0,00)				[0.236–1.467]	[0.031–85.372]	[0.194–1.423]	[0.010–26.026]
	Control	38	22	0	0.185	0.183		p = 0.251	p = 1.000	p = 0.202	p = 1.000
	()	(0,63)	(0,37)	(0,00)
		NN	ND	DD				N versus D	NN versus DD	NN versus ND + DD	NN+ ND versus DD	Common odds ratio and p value
CCR5; (-Δ32)	Case	30	0	0	0,001	0,000	Case versus control	1.992	1.984	1.984	0.504	nan; p = nan
	()	(1,00)	(0,00)	(0,00)				[0.039–101.604]	[0.038–102.405]	[0.038–102.405]	[0.010–26.026]
	Control	60	0	0	0,001	0,000		p = 1.000	p = 1.000	p = 1.000	p = 1.000
	()	(1,00)	(0,00)	(0,00)