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Parkinson’s Disease
Volume 2016, Article ID 5246021, 6 pages
Research Article

Altered Spontaneous Brain Activity in Cortical and Subcortical Regions in Parkinson’s Disease

1College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China
2Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
3Beijing Key Lab of MRI and Brain Informatics, Beijing 100053, China

Received 4 February 2016; Revised 21 May 2016; Accepted 22 May 2016

Academic Editor: Antonio Pisani

Copyright © 2016 Jie Xiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. The present study aimed to explore the changes of amplitude of low-frequency fluctuations (ALFF) at rest in patients with Parkinson’s disease (PD). Methods. Twenty-four PD patients and 22 healthy age-matched controls participated in the study. ALFF was measured on the whole brain of all participants. A two-sample -test was then performed to detect the group differences with age, gender, education level, head motion, and gray matter volume as covariates. Results. It was showed that PD patients had significantly decreased ALFF in the left thalamus/caudate and right insula/inferior prefrontal gyrus, whereas they had increased ALFF in the right medial prefrontal cortex (BA 8/6) and dorsolateral prefrontal cortex (BA 9/10). Conclusions. Our results indicated that significant alterations of ALFF in the subcortical regions and prefrontal cortex have been detected in PD patients, independent of age, gender, education, head motion, and structural atrophy. The current findings further provide insights into the biological mechanism of the disease.