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Parkinson’s Disease
Volume 2016, Article ID 5430920, 5 pages
http://dx.doi.org/10.1155/2016/5430920
Clinical Study

Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-L-m-tyrosine Uptake in the Locus Coeruleus

1Division of Neurology, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan
2Utsunomiya Central Clinic, Tochigi 321-0112, Japan
3Division of Neurology, Jichi Medical University, Tochigi 329-0498, Japan

Received 3 November 2015; Revised 22 January 2016; Accepted 31 January 2016

Academic Editor: Olga L. Lopatina

Copyright © 2016 Sayaka Asari Ono et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Giladi, J. Tal, T. Azulay et al., “Validation of the freezing of gait questionnaire in patients with Parkinson’s disease,” Movement Disorders, vol. 24, no. 5, pp. 655–661, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. B. R. Bloem, J. M. Hausdorff, J. E. Visser, and N. Giladi, “Falls and freezing of gait in Parkinson's disease: a review of two interconnected, episodic phenomena,” Movement Disorders, vol. 19, no. 8, pp. 871–884, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Giladi, M. P. McDermott, S. Fahn et al., “Freezing of gait in PD: prospective assessment in the DATATOP cohort,” Neurology, vol. 56, no. 12, pp. 1712–1721, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Heremans, A. Nieuwboer, J. Spildooren et al., “Cognitive aspects of freezing of gait in Parkinson's disease: a challenge for rehabilitation,” Journal of Neural Transmission, vol. 120, no. 4, pp. 543–557, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. J. G. Nutt, B. R. Bloem, N. Giladi, M. Hallett, F. B. Horak, and A. Nieuwboer, “Freezing of gait: moving forward on a mysterious clinical phenomenon,” The Lancet Neurology, vol. 10, no. 8, pp. 734–744, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Ebersbach, C. Moreau, F. Gandor, L. Defebvre, and D. Devos, “Clinical syndromes: Parkinsonian gait,” Movement Disorders, vol. 28, no. 11, pp. 1552–1559, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. A. J. Espay, P. A. Lewitt, and H. Kaufmann, “Norepinephrine deficiency in Parkinson's disease: the case for noradrenergic enhancement,” Movement Disorders, vol. 29, no. 14, pp. 1710–1719, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Tohgi, T. Abe, and S. Takahashi, “The effects of L-threo-3,4-dihydroxyphenylserine on the total norepinephrine and dopamine concentrations in the cerebrospinal fluid and freezing gait in parkinsonian patients,” Journal of Neural Transmission—Parkinson's Disease and Dementia Section, vol. 5, no. 1, pp. 27–34, 1993. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Fukada, T. Endo, M. Yokoe, T. Hamasaki, T. Hazama, and S. Sakoda, “L-threo-3,4-dihydroxyphenylserine (L-DOPS) co-administered with entacapone improves freezing of gait in Parkinson's disease,” Medical Hypotheses, vol. 80, no. 2, pp. 209–212, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. D. J. Doudet, G. L.-Y. Chan, S. Jivan et al., “Evaluation of dopaminergic presynaptic integrity: 6-[18F]fluoro-L-dopa versus 6-[18F]fluoro-L-m-tyrosine,” Journal of Cerebral Blood Flow and Metabolism, vol. 19, no. 3, pp. 278–287, 1999. View at Google Scholar · View at Scopus
  11. S. Asari, K.-I. Fujimoto, A. Miyauchi, T. Sato, I. Nakano, and S.-I. Muramatsu, “Subregional 6-[18F]fluoro-l-m-tyrosine uptake in the striatum in Parkinson's disease,” BMC Neurology, vol. 11, article 35, 2011. View at Publisher · View at Google Scholar
  12. A. J. Hughes, S. E. Daniel, and A. J. Lees, “Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease,” Neurology, vol. 57, no. 8, pp. 1497–1499, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. D. W. Dickson, H. Braak, J. E. Duda et al., “Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria,” The Lancet Neurology, vol. 8, no. 12, pp. 1150–1157, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. A. L. Bartels, Y. Balash, T. Gurevich, J. D. Schaafsma, J. M. Hausdorff, and N. Giladi, “Relationship between freezing of gait (FOG) and other features of Parkinson's: FOG is not correlated with bradykinesia,” Journal of Clinical Neuroscience, vol. 10, no. 5, pp. 584–588, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. A. L. Bartels and K. L. Leenders, “Brain imaging in patients with freezing of gait,” Movement Disorders, vol. 23, no. 2, pp. S461–S467, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Rubino, F. Assogna, F. Piras et al., “Does a volume reduction of the parietal lobe contribute to freezing of gait in Parkinson's disease?” Parkinsonism & Related Disorders, vol. 20, no. 10, pp. 1101–1103, 2014. View at Publisher · View at Google Scholar
  17. S. Vercruysse, I. Leunissen, G. Vervoort, W. Vandenberghe, S. Swinnen, and A. Nieuwboer, “Microstructural changes in white matter associated with freezing of gait in Parkinson's disease,” Movement Disorders, vol. 30, no. 4, pp. 567–576, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Zarow, S. A. Lyness, J. A. Mortimer, and H. C. Chui, “Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases,” Archives of Neurology, vol. 60, no. 3, pp. 337–341, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Sulzer and D. J. Surmeier, “Neuronal vulnerability, pathogenesis, and Parkinson's disease,” Movement Disorders, vol. 28, no. 6, pp. 715–724, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Braak, K. Del Tredici, U. Rüb, R. A. I. De Vos, E. N. H. Jansen Steur, and E. Braak, “Staging of brain pathology related to sporadic Parkinson's disease,” Neurobiology of Aging, vol. 24, no. 2, pp. 197–211, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Bouret and S. J. Sara, “Network reset: a simplified overarching theory of locus coeruleus noradrenaline function,” Trends in Neurosciences, vol. 28, no. 11, pp. 574–582, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. N. Giladi, D. McMahon, S. Przedborski et al., “Motor blocks in Parkinson's disease,” Neurology, vol. 42, no. 2, pp. 333–339, 1992. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Smulders, R. A. Esselink, B. R. Bloem, and R. Cools, “Freezing of gait in Parkinson's disease is related to impaired motor switching during stepping,” Movement Disorders, vol. 30, no. 8, pp. 1090–1097, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. J. M. Shine, S. L. Naismith, and S. J. G. Lewis, “The pathophysiological mechanisms underlying freezing of gait in Parkinson's Disease,” Journal of Clinical Neuroscience, vol. 18, no. 9, pp. 1154–1157, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. N. I. Bohnen, K. A. Frey, S. Studenski et al., “Extra-nigral pathological conditions are common in Parkinson's disease with freezing of gait: an in vivo positron emission tomography study,” Movement Disorders, vol. 29, no. 9, pp. 1118–1124, 2014. View at Publisher · View at Google Scholar · View at Scopus