Research Article

N-Acetylcysteine in Combination with IGF-1 Enhances Neuroprotection against Proteasome Dysfunction-Induced Neurotoxicity in SH-SY5Y Cells

Figure 3

IGF-1 and NAC increase GSH production and reduce MG132 induced ROS generation in SH-SY5Y cells. Cell cultures were treated with NAC or IGF-1, separately or together, as described for Figure 1, followed by MG132 (5 µM). (a) Glutathione assay results for the control and treated cells versus MG132 treated cells only. (b) Intracellular ROS levels. Level of significance is denoted as and .
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