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Parkinson’s Disease
Volume 2016, Article ID 9531917, 11 pages
http://dx.doi.org/10.1155/2016/9531917
Research Article

Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2

1Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O&N 1, Herestraat 49, P.O. Box 802, 3000 Leuven, Belgium
2Laboratory of Cell Death Research and Therapy, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O&N 1, Herestraat 49, P.O. Box 802, 3000 Leuven, Belgium
3Research Group for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Kapucijnenvoer 33, Blok i, P.O. Box 7001, 3000 Leuven, Belgium
4Leuven Viral Vector Core, KU Leuven, Kapucijnenvoer 33, Blok i, P.O. Box 7001, 3000 Leuven, Belgium

Received 29 December 2015; Accepted 23 February 2016

Academic Editor: José M. Fuentes

Copyright © 2016 Shaun Martin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [5 citations]

The following is the list of published articles that have cited the current article.

  • Demirsoy, Agostinis, Martin, Motamedi, van Veen, Holemans, Van den Haute, Jordanova, Baekelandt, and Vangheluwe, “ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function,” Human Molecular Genetics, vol. 26, no. 9, pp. 1656–1669, 2017. View at Publisher · View at Google Scholar
  • Jianfeng Li, Jun-Ping Liu, Yanhua Lu, Lihui Wang, and Gang Chen, “Impulse control disorder, lysosomal malfunction and ATP13A2 insufficiency in Parkinsonism,” Clinical and Experimental Pharmacology and Physiology, vol. 44, no. 2, pp. 172–179, 2017. View at Publisher · View at Google Scholar
  • Dae-In Chang, Danny Mollerup Sørensen, Bob Asselbergh, Christine Klein, Stephan Zuchner, Albena Jordanova, Peter Vangheluwe, Rebecca Schüle, Matthis Synofzik, Dagmar Timmann, Albena Andreeva, Jennifer Reichbauer, Riet De Rycke, Alejandro Estrada-Cuzcano, Sarah Van Veen, Jean Samuel, Ludger Schöls, Thorsten Pöppel, Shaun Martin, Ivailo Tournev, Teodora Chamova, and Tine Holemans, “Loss-of-function mutations in the ATP13A2/PARK9 gene cause complicated hereditary spastic paraplegia (SPG78),” Brain, vol. 140, no. 2, pp. 287–305, 2017. View at Publisher · View at Google Scholar
  • Danny Mollerup Sørensen, Tine Holemans, Sarah van Veen, Shaun Martin, Tugce Arslan, Ida Winther Haagendahl, Henrik Waldal Holen, Norin Nabil Hamouda, Jan Eggermont, Michael Palmgren, and Peter Vangheluwe, “Parkinson disease related ATP13A2 evolved early in animal evolution,” Plos One, vol. 13, no. 3, pp. e0193228, 2018. View at Publisher · View at Google Scholar
  • Veronick Benoy, Lawrence Van Helleputte, Robert Prior, Constantin d’Ydewalle, Wanda Haeck, Natasja Geens, Wendy Scheveneels, Begga Schevenels, M. Zameel Cader, Kevin Talbot, Alan P. Kozikowski, Pieter Vanden Berghe, Philip Van Damme, Wim Robberecht, and Ludo Van Den Bosch, “HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease,” Brain, 2018. View at Publisher · View at Google Scholar