TY - JOUR
A2 - Berwick, Daniel
AU - Bouhouche, Ahmed
AU - Tibar, Houyam
AU - Ben El Haj, Rafiqua
AU - El Bayad, Khalil
AU - Razine, Rachid
AU - Tazrout, Sanaa
AU - Skalli, Asmae
AU - Bouslam, Naima
AU - Elouardi, Loubna
AU - Benomar, Ali
AU - Yahyaoui, Mohammed
AU - Regragui, Wafa
PY - 2017
DA - 2017/03/30
TI - LRRK2 G2019S Mutation: Prevalence and Clinical Features in Moroccans with Parkinson’s Disease
SP - 2412486
VL - 2017
AB - Background. The LRRK2 G2019S mutation is the most common genetic determinant of Parkinson’s disease (PD) identified to date. This mutation, reported in both familial and sporadic PD, occurs at elevated frequencies in Maghreb population. In the present study, we examined the prevalence of the G2019S mutation in the Moroccan population and we compared the motor and nonmotor phenotype of G2019S carriers to patients with idiopathic Parkinson’s disease. Methods. 100 PD patients were assessed for motor and nonmotor symptoms, current medication, and motor complication including motor fluctuations and dyskinesia. The LRRK2 G2019S mutation was investigated by direct sequencing in patients and ethnically matched controls, all of Moroccan origin. Results. Among the 100 PD Moroccan patients, 41 (41%) were carriers of the G2019S mutation. The mutation frequency was higher among probands with autosomal dominant inheritance (76%) than among sporadic ones (28%). Interestingly, G2019S mutation was also found in 5% of control individuals. Clinically, patients carrying the G2019S mutation have more dystonia (OR = 4.6, p = 0.042) and more sleep disorders (OR = 2.4, p = 0.045) than noncarriers. Conclusions. The LRRK2 G2019S prevalence in Morocco is the highest in the world reported to date. Some clinical features in G2019S carriers such as dystonia and sleep disturbances are worth noting.
SN - 2090-8083
UR - https://doi.org/10.1155/2017/2412486
DO - 10.1155/2017/2412486
JF - Parkinson’s Disease
PB - Hindawi
KW -
ER -