Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration

<div>Localisation of SIRT2 and <i>α</i>-synuclein in rotenone treated SH-SY5Y cells. Cellular distribution of SIRT2 and phospho-<i>α</i>-synuclein was determined using fluorescent immunocytochemistry. Images show <i>α</i>-synuclein immunostaining, SIRT2 immunostaining, and all staining merged including DAPI in 20 <i>μ</i>M rotenone treated cells. Scale bars, white scale bar = 50 <i>μ</i>M and red scale bar = 20 <i>μ</i>M; magnification: 40x. (a) represents 0.2% DMSO and (b) represents 20 <i>μ</i>M rotenone treated SH-SY5Y cells.</div>

Parkinson’s Disease

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Figure 4

Figure 4: Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration 