Genetic Variations and mRNA Expression of NRF2 in Parkinson’s Disease

Figure 2

mRNA levels do not correlate with age. NRF2 mRNA expression in EBV transfected lymphocytes from individuals of different age spanning from 40 years to 80; PD patients are represented in black and controls in white. Each data point corresponds to the mean value of triplicates normalized to GAPDH and to a reference sample consisting of cDNA from all control individuals; error bars: standard error of mean. Correlation between age and expression of NRF2 was evaluated using linear regression and was found nonsignificant (slope = 0.0068, ) when the entire material was analyzed regardless of disease and when controls were analyzed separately (regression line not shown, slope = 0.060, ).