Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals

Figure 7

Short-term and long-term effects of DBS with uni- and bipolar electrodes on the akinesia of hemiparkinsonian rats as measured by the initiation time of the first adjusting step of the ipsilateral forepaw in the stepping test. (a) and (b) refer to test groups and controls, respectively. The dashed line at 1 s allows for an easier comparison with Figure 6 and between (a) and (b). Different column patterns indicate different times of behavioral testing; white: before 6-OHDA or sham lesion; black: 12–14 days after 6-OHDA or sham lesion; gray and hatched: after the durations of DBS or sham stimulation indicated in the group labels. For experimental details see Table 1. Significance levels are indicated with asterisks as follows: , , b (borderline): according to one-way ANOVA. Asterisks above black columns refer to white columns; all others refer to black columns.

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